MTNR1A epigenetic activation in aged porcine oocytes
CRISPR/dCas9-Tet1 activation of MTNR1A to restore redox defense, gap junction communication, and oocyte competence.
RolePrincipal investigator
FocusPorcine cumulus-oocyte complexes, IVM, CRISPR/dCas9-Tet1, MTNR1A promoter demethylation, NRF2, Cx43 gap junctions.
OutcomeSubmitted manuscript on MTNR1A epigenetic activation rescuing aging-related redox and communication deficits in oocytes.